Latest News

We are delighted to announce the introduction of the FOCUS4-C comparison to the FOCUS4 Trial Programme, which has received MHRA, HRA and Ethics approvals. We have also removed the high platelets exclusion criterion from the Master Protocol and made some other eligibility changes.

For information on how you can process this amendment and activate your site to FOCUS4-C, please see the Activation Notification document, which was e-mailed to all sites and is also found in the Investigators Area. The substantial amendment documents and new template documents can be found in the Investigators Area of our website.


Aims & Objectives

The primary research objectives fall into 3 main categories:

  • Clinical Benefit
  • Trial Design Improvement
  • Biomarker Research
Objectives in detail
Eligibility for Participation

As with all clinical trials, there are a set of criteria that patients need to meet before they can be offered entry into the trial. Sites must comply with the inclusion criteria to be considered.

Eligibility: Patients Eligibility: Sites
Investigators Area

Access all the required documentation for site set-up such as: :

  • Ethics approval documents
  • MHRA approval documents
  • R&D approval documents
  • Protocol Amendments
Members Area
Are you interested in participating in FOCUS4?

Find out if you can participate in FOCUS4 and which current UK Hospitals are currently recruiting.

Eligibility: Patients Site List

Target Recruitment

FOCUS4 aims to register 2400 and randomise at least 1536 patients from over 100 hospitals across the whole of the UK.


Click here to see the target recruitment figures....

Overall Recruitment

FOCUS4 started recruitment in January 2014, and is currently open to recruitment

Click here to see the overall recruitment figures...

Centre Recruitment

There are 103 sites open in the UK recruiting to FOCUS4.



See the recruitment figures for each site here...

Trial Committees and Investigators

There are a number of committees involved with the oversight of the trial.

Click here to see more about who they are and what they do...