Welcome to FOCUS4

FOCUS4 is a molecularly stratified, multi-site randomised trial programme for patients with colorectal cancer opening in the UK in 2014.

The FOCUS4 programme is designed to identify and register eligible patients, perform a set of molecular tests on a sample of their tumour and then enrol them into a specific randomised trial based on the results of the molecular tests. Each molecularly stratified trial aims to compare a novel intervention to placebo or standard care. Please follow the links on the left for detailed information on the trial.

FOCUS4 News!

We are delighted to announce the introduction of the FOCUS4-C comparison to the FOCUS4 Trial Programme, which has received MHRA, HRA and Ethics approvals. We have also removed the high platelets exclusion criterion from the Master Protocol and made some other eligibility changes.

For information on how you can process this amendment and activate your site to FOCUS4-C, please see the Activation Notification document, which was e-mailed to all sites and is also found in the Investigators Area. The substantial amendment documents and new template documents can be found in the Investigators Area of our website.

Please note these facilities will be closed for maintenance on the following dates:

-          FOCUS4 Website on Tuesday 13th June

-          eDC via MACRO Tuesday 27th June


Be sure check out the FOCUS4 DVD here


Best regards

The FOCUS4 team

Last Updated:

Latest Recruitment
FOCUS4 opened to recruitment in January 2014.
Total Patients registered : 643
Total Patients randomised : 174


  • February 2016 - FOCUS4-B opens to recruitment
  • January 2014: Open to Registration Recruitment for 4-5 years followed by 2 years follow-up
  • September 2013: Second launch meeting in Leeds
  • August-September 2013: Site set up
  • July 2013: First launch meeting in London
  • May 2013: Ethics approval obtained
  • April 2013: MHRA approval obtained
  • March 2013 : Funding contracts signed
  • July 2012: Grant award email from EME
  • Feb 2012: Approved by MRC/NIHR EME Programme for intention to fund
  • November 2011: approved by CR-UK as a flagship trial for biomarker driven multi-arm, multi-stage design

Launch Meetings

17th September 2013 - Devonshire Hall,Leeds                                                                                                                                        9th July 2013 - Wellcome Collection, London

Launch meeting agenda