The FOCUS4 programme was designed to identify and register eligible patients, perform a set of molecular tests on a sample of their tumour and then enrol them into a specific randomised trial based on the results of the molecular tests. Each molecularly stratified trial aimed to compare a novel intervention to placebo or standard care. Please follow the links above for detailed information on the trial and click on the 'News' tab above for links to the publications.


We would like to thank all the patients who took part in FOCUS4 and all the investigators who worked on the trial (see a full list of all the investigators here)

 Focus 4 Schema

Aims & Objectives

The primary research objectives fall into 3 main categories:

  • Clinical Benefit
  • Trial Design Improvement
  • Biomarker Research
Objectives in detail
Investigators Area

Access all the required documentation for site set-up and site closure such as: :

  • Ethics approval documents
  • MHRA approval documents
  • R&D approval documents
  • Protocol Amendments
Members Area
Sites  participating in FOCUS4

List of UK hospitals that participated in the trial.



Target Recruitment

FOCUS4 aimed to register 2400 and randomise at least 1536 patients from over 100 hospitals across the whole of the UK.


Click here to see the target recruitment figures....

Overall Recruitment

FOCUS4 started recruitment in January 2014, and closed to recruitment in October 2020.

Click here to see the overall recruitment figures...

Centre Recruitment

There were 94 sites open in the UK that recruited to FOCUS4.



See the recruitment figures for each site here...

Trial Committees and Investigators

There are a number of committees involved with the oversight of the trial.

Click here to see more about who they are and what they do...