Welcome to FOCUS4

FOCUS4 is a molecularly stratified, multi-site randomised trial programme for patients with colorectal cancer opening in the UK in 2014.

The FOCUS4 programme is designed to identify and register eligible patients, perform a set of molecular tests on a sample of their tumour and then enrol them into a specific randomised trial based on the results of the molecular tests. Each molecularly stratified trial aims to compare a novel intervention to placebo or standard care. Please follow the links on the left for detailed information on the trial.

FOCUS4 News!

FOCUS4-C is coming! Documents for the FOCUS4-C amendment have been submitted and will be circulated within the next month.

Please note the Insurance Certificate for August 2016-17 is now available to download from the investigator area. Please ensure this is filed in your site file.



Be sure check out the FOCUS4 DVD here


Best regards

The FOCUS4 team

Last Updated:

Latest Recruitment
FOCUS4 opened to recruitment in January 2014.
Total Patients registered : 494
Total Patients randomised : 132


  • February 2016 - FOCUS4-B opens to recruitment
  • January 2014: Open to Registration Recruitment for 4-5 years followed by 2 years follow-up
  • September 2013: Second launch meeting in Leeds
  • August-September 2013: Site set up
  • July 2013: First launch meeting in London
  • May 2013: Ethics approval obtained
  • April 2013: MHRA approval obtained
  • March 2013 : Funding contracts signed
  • July 2012: Grant award email from EME
  • Feb 2012: Approved by MRC/NIHR EME Programme for intention to fund
  • November 2011: approved by CR-UK as a flagship trial for biomarker driven multi-arm, multi-stage design

Launch Meetings

17th September 2013 - Devonshire Hall,Leeds                                                                                                                                        9th July 2013 - Wellcome Collection, London

Launch meeting agenda