News

 

The FOCUS4 trial has now published the results of the trial. Please find below a list of each of these publications.

 

FOCUS4 Publications:

2022 FOCUS4 biomarker laboratories: from the benefits to the practical and logistical issues faced during 6 years of centralised testing Journal of Clinical Pathology

2022 Experiences of running a stratified medicine adaptive platform trial: Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer SAGE Journals

2021 Inhibition of WEE1 Is Effective in TP53- and RAS-Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring. Journal of Clinical Oncology

2021 Capecitabine Versus Active Monitoring in Stable or Responding Metastatic Colorectal Cancer After 16 Weeks of First-Line Therapy: Results of the Randomized FOCUS4-N Trial. Journal of Clinical Oncology

2021 Treatment Holidays for Patients With Metastatic Colorectal Cancer. Journal of Clinical Oncology

2021 Treatment breaks in first line treatment of advanced colorectal cancer: An individual patient data meta-analysis. Cancer treatment Reviews 

2019 This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols BioMed Central

2019 Mind the gap? The platform trial as a working environment BioMed Central

2019 Changing platforms without stopping the train: experiences of data management and data management systems when adapting platform protocols by adding and closing comparisons BioMed Central

2017 Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols SAGE Journals

2017 Inhibition of EGFR, HER2, and HER3 signalling in patients with colorectal cancer wild-type for BRAF, PIK3CA, KRAS, and NRAS (FOCUS4-D): a phase 2–3 randomised trial. The Lancet. Gastroenterology & hepatology

2017 The Promise and the Hype of ‘Personalised Medicine’. The New bioethics 

2015 Pre-trial inter-laboratory analytical validation of the FOCUS4 personalised therapy trial. Journal of Clinical Pathology 

2013 Evaluating Many Treatments and Biomarkers in Oncology: A New Design. Journal of Clinical Oncology

 

FOCUS4 Posters:

NCRI 2016 Poster FOCUS4-D 

 

 FOCUS4 Presentations:

FOCUS4C Trial Results ESMO 2021

FOCUS4N Trial Results ASCO 2021

FOCUS4

MRC Clinical Trials Unit at UCL
Institute of Clinical Trials & Methodology

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London
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Email. mrcctu.focus4@ucl.ac.uk