MRC Clinical Trials Unit at UCL
Institute of Clinical Trials & Methodology
90 High Holborn
2nd Floor
London
WC1V 6LJ
Email. mrcctu.focus4@ucl.ac.uk
FOCUS4-C Concomitant medication
If you are taking AZD1775 and you are prescribed any of the following medication please can you contact your oncology Doctor before taking:
Prohibited Medications
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ABT-384 ACT-178882 Alfentanil Alfuzosin Almorexant Alpha-Dihydroergocryptine Amiodarone Aprepitant Astemizole Atorvastatin Avanafil Avasimibe Bexarotine Bosentan Brotizolam Budesonide Buspirone Carbamazepine Casopitant Ciprofloxacin Cisapride Clarithromycin Conivaptan Darifenacin Dihydroergotamine Diltiazem Disopyramide Dofetilide Dronedarone Ebastine Eletriptan
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Eplerenone Ergotamine Erythromycin Felodipine Fentanyl Fluticasone FK1706 Fluconazole Genistein Grapefruit juice Halofantrine Ivacaftor Itraconazole Levomethadyl (LAAm) Lomitapide Lovastatin Lurasidone L-771,688 Ketoconazole Mibefradil Midazolam Modafinil Mosapride Nafcillin Nefazodone Netupitant Nisoldipine Perospirone Phenobarbital Phenytoin Pimozide Posaconazole |
Propafenone Propofol Quetiapine Quinidine Ranolazine Rifabutin Rifampin Schisandra Sphenanthera Semagacestat Sildenafil Simvastatin Sirolimus Tacrolimus Temsirolimus St John's Wort Telithromycin Terfenadine Thioridazine Ticagrelor Theoophylline Tilidine Tofisopam Tolvaptan Tretinoin Triazolam Troleandomycin Ulipristal Vardenafil Verapamil Voclosporin Voriconazole |
Use with Caution Medications
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Alosetron Aspirin (high dose) Caffeine Celecoxib Colchicine Cyclosporine Diazepam Diclofenac Digoxin Duloxetine Etoricoxib Fexofenadine Gliclazide Ibuprofen Indometacin Lansoprazole LY335979Quinidine (R)-Lansoprazole
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Melatonin (S)-Mephenytoin (R)-Mephobarbital Metformin Omeprazole Pantoprazole Rabeprazole Ramelteon Sulfasalazine Tacrine Theophylline Tilidine Tizanidine
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If you are the doctor of a patient taking AZD1775, please follow the link for more information on the medications above
FOCUS4