MRC Clinical Trials Unit at UCL
Institute of Clinical Trials & Methodology
90 High Holborn
FOCUS4 is now open to recruitment.
FOCUS4 aims to register 2400 and randomise at least 1536 patients from over 100 hospitals across the whole of the UK. Previous research has shown that this number of hospitals can screen about 70 patients per month and the distribution of molecular cohorts will be similar to those in Table 1 below. Therefore, we aim to recruit for 4-5 years to reach our target recruitment of at least 1536 patients.
|Table 1||70 screened patients per month|
|Molecular cohort||Prevalence||Randomised patients/mth||Total over 4 years||Total over 5 years|
|PIK3CA mutation and/or PTEN loss||30%||9.6||461||576|
|KRAS or NRAS mutation||33%||10.6||509||636|