FOCUS4 Recruitment

FOCUS4 is now open to recruitment.

Overall recruitment
Centre recruitment

TARGET RECRUITMENT

FOCUS4 aims to register 2400 and randomise at least 1536 patients from over 100 hospitals across the whole of the UK. Previous research has shown that this number of hospitals can screen about 70 patients per month and the distribution of molecular cohorts will be similar to those in Table 1 below. Therefore, we aim to recruit for 4-5 years to reach our target recruitment of at least 1536 patients.
Table 1 70 screened patients per month
Molecular cohort Prevalence Randomised patients/mth Total over 4 years Total over 5 years
Total 100% 32 1536 1920
BRAF mutation 8% 2.6 125 156
PIK3CA mutation and/or PTEN loss 30% 9.6 461 576
KRAS or NRAS mutation 33% 10.6 509 636
EGFR dependent 27% 8.6 413 516
Non-stratified 2% 0.6 28 36